- Dual C32 sockets support up to (2) AMD Opteron™ processors 4100 series (codenamed Lisbon)
- Support (2) HyperTransport™ 3.0 link, max. bandwidth up to 25.6 GB/s @ 6.4GT/s per link
- AMD SR5690 + SR5650 + SP5100 (S8226WGM3NR-HE)
- AMD SR5690 + SP5100 (S8226WGM3NR/ S8226GM3NR)
- (12) 240-pin DDR3 DIMM slots support up to 192GB R-DDR3 1333/1066/800MHz w/ ECC memory
- (2) PCI-E Gen.2 x16 slots (S8226GM3NR/ S8226WGM3NR)
- (3) PCI-E Gen.2 x16 slots (S8226WGM3NR-HE)
- (6) SATA-II ports via (1) Mini-SAS & (2) SATA connectors w/ RAID 0, 1, 10, 5 support
- (8) SAS 6G ports via (2) Mini-SAS connectors w/ RAID 0, 1, 1E, 10 support (S8226WGM3NR-HE/ S8226GM3NR)
- (3) GbE LAN
- Onboard BMC w/ IPMI and iKVM support.